Professor F. Blaine Hollinger

F. Blaine Hollinger, M.D.




  • Professor
  • Virology & Microbiology: Hollinger Lab
  • Baylor College of Medicine
  • Houston, Texas


  • Eugene B. Casey Hepatitis Research Center and Diagnostic Laboratory
  • Houston, Texas



  • MD from University Of Kansas
  • 01/1957 - Lawrence, KS, United States
  • Fellowship at Baylor College Of Medicine Affiliate Hospitals
  • 01/1968 - Houston, TX, United States
  • NIH Special Fellow, Department of Virology & Epidemiology
  • Internship at University of California - San Francisco
  • 01/1966 - San Francisco, CA
  • Internal Medicine
  • Residency at University of Kansas Medical Center
  • 01/1965 - Kansas City, KS
  • Internal Medicine
  • Residency at University Of Washington Hospital
  • 01/1964 - Seattle, WA, United States
  • Residency at University Of California Hospitals & Clinics
  • 01/1962 - San Francisco, CA, United States





List of Publications:

  • 1: Hollinger FB. Should Evidence-based Medicine Be Used to Design Clinical Practice Guidelines for the Prevention of Perinatal Transmission of Hepatitis B Virus From Hepatitis B e Antigen-Positive Mothers? Clin Gastroenterol Hepatol. 2015 Jun;13(6):1177-80. doi: 10.1016/j.cgh.2015.02.016. Epub 2015 Feb 18. PubMed PMID: 25701701.
  • 2: Tansel A, Kanwal F, Hollinger FB. Use of Hy's Law, R criteria, and nR criteria to predict acute liver failure or transplantation in patients with drug-induced liver injury. Gastroenterology. 2015 Feb;148(2):452. doi: 10.1053/j.gastro.2014.11.046. Epub 2014 Dec 19. PubMed PMID: 25532807.
  • 3: Hollinger FB, Dodd RY. Hepatitis B virus traceback and lookback: factors to consider. Transfusion. 2009 Jan;49(1):176-84. doi: 10.1111/j.1537-2995.2008.01961.x. Review. PubMed PMID: 19140810.
  • 4: Hollinger FB. Hepatitis B virus infection and transfusion medicine: science and the occult. Transfusion. 2008 May;48(5):1001-26. doi: 10.1111/j.1537-2995.2008.01701.x. Review. PubMed PMID: 18454738.
  • 5: Hollinger FB, Kleinman S. Transfusion transmission of West Nile virus: a merging of historical and contemporary perspectives. Transfusion. 2003 Aug;43(8):992-7. Review. PubMed PMID: 12869102.
  • 6: Hollinger FB. Factors contributing to the evolution and outcome of cirrhosis in hepatitis C. Clin Liver Dis. 1999 Nov;3(4):741-55, viii. Review. PubMed PMID: 11291248.
  • 7: Lin HJ, Siwak EB, Lauder IJ, Hollinger FB. Long-term culture of human immunodeficiency virus type 1 resulting in loss of glycosylation sites. J Med Virol. 2001 Mar;63(3):197-202. PubMed PMID: 11170057.
  • 8: Hollinger FB. Overview of viral hepatitis. Int J Circumpolar Health. 1998;57 Suppl 1:276-9. PubMed PMID: 10093289.
  • 9: Lee WM, Reddy KR, Tong MJ, Black M, van Leeuwen DJ, Hollinger FB, Mullen KD, Pimstone N, Albert D, Gardner S. Early hepatitis C virus-RNA responses predict interferon treatment outcomes in chronic hepatitis C. The Consensus Interferon Study Group. Hepatology. 1998 Nov;28(5):1411-5. PubMed PMID: 9794929.
  • 10: Lin HJ, Siwak EB, Lauder IJ, Hollinger FB. Selection of appropriate HIV-1 genomic regions for single-strand conformation polymorphism analysis of the diversity, modification, and transmission of HIV-1 quasispecies. J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Aug 15;18(5):409-16. PubMed PMID: 9715836.
  • 11: Lin HJ, Pedneault L, Hollinger FB. Intra-assay performance characteristics of five assays for quantification of human immunodeficiency virus type 1 RNA in plasma. J Clin Microbiol. 1998 Mar;36(3):835-9. PubMed PMID: 9508327; PubMed Central PMCID: PMC104640.
  • 12: Troisi CL, Hollinger FB. Detection of antibodies to hepatitis C virus in seronegative patients using an immune complex dissociation assay. J Viral Hepat. 1997;4(6):383-6. PubMed PMID: 9430358.
  • 13: Lin HJ, Tanwandee T, Hollinger FB. Improved methods for quantification of human immunodeficiency virus type 1 RNA and hepatitis C virus RNA in blood using spin column technology and chemiluminescent assays of PCR products. J Med Virol. 1997 Jan;51(1):56-63. PubMed PMID: 8986950.
  • 14: Lin HJ, Haywood M, Hollinger FB. Application of a commercial kit for detection of PCR products to quantification of human immunodeficiency virus type 1 RNA and proviral DNA. J Clin Microbiol. 1996 Feb;34(2):329-33. PubMed PMID: 8789009; PubMed Central PMCID: PMC228791.
  • 15: Hollinger FB. Comprehensive control (or elimination) of hepatitis B virus transmission in the United States. Gut. 1996;38 Suppl 2:S24-30. Review. PubMed PMID: 8786049; PubMed Central PMCID: PMC1398039.
  • 16: Qavi HB, Green MT, Lewis DE, Hollinger FB, Pearson G, Ablashi DV. HIV-1 and HHV-6 antigens and transcripts in retinas of patients with AIDS in the absence of human cytomegalovirus. Invest Ophthalmol Vis Sci. 1995 Sep;36(10):2040-7. PubMed PMID: 7657542.
  • 17: Hollinger FB, Mouneimne Y, Lahart C, Tosi PF, Dimitrov D, Nicolau C. Life span of circulating membrane CD4 inserted into the plasma membranes of autologous red blood cells of HIV-infected subjects. J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jun 1;9(2):126-32. PubMed PMID: 7749788.
  • 18: Hollinger FB, Eickhoff T, Gershon A, Jong EC, Koff RS. Discussion: who should receive hepatitis A vaccine? A strategy for controlling hepatitis A in the United States. J Infect Dis. 1995 Mar;171 Suppl 1:S73-7. PubMed PMID: 7876653.
  • 19: Lewis DE, Adu-Oppong A, Hollinger FB, Rosenblatt HM, Hanson IC, Reuben JM, Kline MW, Kozinetz CA, Shearer WT. Sensitivity of immune complex-dissociated p24 antigen testing for early detection of human immunodeficiency virus in infants. Clin Diagn Lab Immunol. 1995 Jan;2(1):87-90. PubMed PMID: 7719918; PubMed Central PMCID: PMC170106.
  • 20: Lin HJ, Myers LE, Yen-Lieberman B, Hollinger FB, Henrard D, Hooper CJ, Kokka R, Kwok S, Rasheed S, Vahey M, et al. Multicenter evaluation of quantification methods for plasma human immunodeficiency virus type 1 RNA. J Infect Dis. 1994 Sep;170(3):553-62. PubMed PMID: 7915748.
  • 21: Han KH, Hollinger FB, Noonan CA, Solomon H, Klintmalm GB, Genta RM, Yoffe B. Southern-blot analysis and simultaneous in situ detection of hepatitis B virus-associated DNA and antigens in patients with end-stage liver disease. Hepatology. 1993 Nov;18(5):1032-8. PubMed PMID: 8225208.
  • 22: Dimitrov DH, Hollinger FB, Baker CJ, Kline MW, Doyle M, Bremer JW, Shearer WT. Study of human immunodeficiency virus resistance to 2'-3'-dideoxyinosine and zidovudine in sequential isolates from pediatric patients on long-term therapy. J Infect Dis. 1993 Apr;167(4):818-23. PubMed PMID: 8450246.
  • 23: Lin HJ, Shi N, Mizokami M, Hollinger FB. Polymerase chain reaction assay for hepatitis C virus RNA using a single tube for reverse transcription and serial rounds of amplification with nested primer pairs. J Med Virol. 1992 Nov;38(3):220-5. PubMed PMID: 1337550.
  • 24: Mathur S, Verseman S, Estrada R, Hollinger FB. Bleeding from a Meckel's diverticulum after the use of ibuprofen. Am J Gastroenterol. 1992 Oct;87(10):1467-70. PubMed PMID: 1415106.
  • 25: Qavi HB, Green MT, SeGall GK, Lewis DE, Hollinger FB. Transcriptional activity of HIV-1 and HHV-6 in retinal lesions from AIDS patients. Invest Ophthalmol Vis Sci. 1992 Sep;33(10):2759-67. PubMed PMID: 1326493.
  • 26: Hollinger FB, Bremer JW, Myers LE, Gold JW, McQuay L. Standardization of sensitive human immunodeficiency virus coculture procedures and establishment of a multicenter quality assurance program for the AIDS Clinical Trials Group. The NIH/NIAID/DAIDS/ACTG Virology Laboratories. J Clin Microbiol. 1992 Jul;30(7):1787-94. PubMed PMID: 1629336; PubMed Central PMCID: PMC265382.
  • 27: Han KH, Hollinger FB, Noonan CA, Yoffe B. Simultaneous detection of HBV-specific antigens and DNA in paraffin-embedded liver tissue by immunohistochemistry and in situ hybridization using a digoxigenin-labeled probe. J Virol Methods. 1992 Apr;37(1):89-97. PubMed PMID: 1572934.
  • 28: Dimitrov DH, Melnick JL, Hollinger FB. Microculture assay for isolation of human immunodeficiency virus type 1 and for titration of infected peripheral blood mononuclear cells. J Clin Microbiol. 1990 Apr;28(4):734-7. PubMed PMID: 2332470; PubMed Central PMCID: PMC267785.
  • 29: Hollinger FB. Controlling hepatitis B virus transmission in North America. The North American Regional Study Group. Vaccine. 1990 Mar;8 Suppl:S122-8; discussion S134-8. PubMed PMID: 2139279.
  • 30: Hollinger FB. Factors influencing the immune response to hepatitis B vaccine, booster dose guidelines, and vaccine protocol recommendations. Am J Med. 1989 Sep 4;87(3A):36S-40S. Review. PubMed PMID: 2528297.
  • 31: Yoffe B, Petrie BL, Noonan CA, Hollinger FB. In vivo and in vitro ultrastructural alterations induced by human immunodeficiency virus in human lymphoid cells. Lab Invest. 1989 Sep;61(3):303-9. PubMed PMID: 2570180.
  • 32: Garcia G, Hollinger FB. Hepatitis B virus infection and renal transplantation. Hepatology. 1988 Sep-Oct;8(5):1172-4. PubMed PMID: 3047040.
  • 33: Lewis DE, Yoffe B, Bosworth CG, Hollinger FB, Rich RR. Human immunodeficiency virus-induced pathology favored by cellular transmission and activation. FASEB J. 1988 Mar 1;2(3):251-5. PubMed PMID: 2965047.
  • 34: Pepe PE, Hollinger FB, Troisi CL, Heiberg D. Viral hepatitis risk in urban emergency medical services personnel. Ann Emerg Med. 1986 Apr;15(4):454-7. PubMed PMID: 3954182.
  • 35: Troisi CL, Heiberg DA, Hollinger FB. Normal immune response to hepatitis B vaccine in patients with Down's syndrome. A basis for immunization guidelines. JAMA. 1985 Dec 13;254(22):3196-9. PubMed PMID: 2933533.
  • 36: Maynard JE, Bradley DW, Hornbeck CL, Fields RM, Doto IL, Hollinger FB. Preliminary serologic studies of antibody to hepatitis A virus in populations in the United States. J Infect Dis. 1976 Nov;134(5):528-30. PubMed PMID: 186542.
  • 37: Williams KH, Hollinger FB, Metzger WR, Hopkins CC, Chamberlain RW. The epidemiology of St. Louis encephalitis in Corpus Christi, Texas, 1966. Am J Epidemiol. 1975 Jul;102(1):16-24. PubMed PMID: 1155434.
  • 38: Hopkins CC, Hollinger FB, Johnson RF, Dewlett HJ, Newhouse VF, Chamberlain RW. The epidemiology of St. Louis encephalitis in Dallas, Texas, 1966. Am J Epidemiol. 1975 Jul;102(1):1-15. PubMed PMID: 1155433.
  • 39: Hollinger FB, Goyal RK, Hersh T, Powell HC, Schulman RJ, Malnick JL. Immune response to hepaitis virus type B in Down's syndrome and other mentally retarded patients. Am J Epidemiol. 1972 Apr;95(4):356-62. PubMed PMID: 4259384.