Professor Frank Tacke

 

  • Prof. Dr. Frank Tacke, MD, PhD
  • University Hospital Aachen
  • Dept of Medicine III
  • Pauwelsstr 30
  • D-52074 Aachen
  • Germany

Frank Tacke was originally educated at the medical school in Hannover, Germany, and Baylor College of Medicine, Houston, TX. Later he stayed at University of Texas, M.D. Anderson Cancer Center in Houston, working on new gene therapy strategies (1998-1999) as well as for a post-doctoral research training (2004-2006) at the Mount Sinai Medical Center, New York, working on monocyte/macrophage and dendritic cell biology. Since 2006, he is a clinical physician and leader of a research laboratory at the University Hospital Aachen, Germany. He is board-certified in Internal Medicine, Gastroenterology and Critical Care Medicine. His research interests are: Clinical and Experimental Hepatology, Liver Immunology, Viral Hepatitis, Gastroenterology, Critical Care Medicine, and Monocyte/Macrophage Biology. In 2012, Frank Tacke was appointed as an Associate Professor (W2-professorship) at the RWTH University Aachen. He has (co‑)authored >180 peer-reviewed original and review articles.

 

For the last several years, important lines of research in Frank Tacke’s research team included the regulation of inflammatory responses in the liver, novel imaging approaches to dissect immune cell subsets in injured liver, factors driving the progression to fibrosis and cancer, targeting these cellular or molecular mechanisms by nanoparticles and the translation into clinics (biomarkers + therapy). He has been furthermore involved in several clinical trials, mainly focussed on improving therapies for acute liver failure, chronic hepatitis B, hepatitis C, liver cirrhosis and hepatocellular carcinoma.

 

 


 

Link:

EASL SCIENTIFIC COMMITTEE MEMBERS


List of Publications:

  • 1: Koppe C, Verheugd P, Gautheron J, Reisinger F, Kreggenwinkel K, Roderburg C, Quagliata L, Terracciano L, Gassler N, Tolba RH, Boege Y, Weber A, Karin M, Luedde M, Neumann UP, Weiskirchen R, Tacke F, Vucur M, Trautwein C, Lüscher B, Preisinger C, Heikenwalder M, Luedde T. IKKα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator RIPK1. Hepatology. 2016 Jul 11. doi: 10.1002/hep.28723. [Epub ahead of print] PubMed PMID: 27396433.
  • 2: Sadeghi A, Shirvani-Dastgerdi E, Tacke F, Yagmur E, Poortahmasebi V, Poorebrahim M, Mohraz M, Hajabdolbaghi M, Rasoolinejad M, Abbasian L, Jafari R, Fakhari Z, Norouzi M, Ebrahimian A, Geravand B, Alavian SM, Jazayeri SM. HBsAg mutations related to occult hepatitis B virus infection in HIV-positive patients result in a reduced secretion and conformational changes of HBsAg. J Med Virol. 2016 Jul 6. doi: 10.1002/jmv.24623. [Epub ahead of print] PubMed PMID: 27381922.
  • 3: Gautheron J, Vucur M, Schneider AT, Severi I, Roderburg C, Roy S, Bartneck M, Schrammen P, Diaz MB, Ehling J, Gremse F, Heymann F, Koppe C, Lammers T, Kiessling F, Van Best N, Pabst O, Courtois G, Linkermann A, Krautwald S, Neumann UP, Tacke F, Trautwein C, Green DR, Longerich T, Frey N, Luedde M, Bluher M, Herzig S, Heikenwalder M, Luedde T. The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance. Nat Commun. 2016 Jun 21;7:11869. doi: 10.1038/ncomms11869. PubMed PMID: 27323669; PubMed Central PMCID: PMC4919522.
  • 4: Liepelt A, Tacke F. Stromal cell-derived factor-1 (SDF-1) as a target in liver diseases. Am J Physiol Gastrointest Liver Physiol. 2016 Jun 16:ajpgi.00193.2016. doi: 10.1152/ajpgi.00193.2016. [Epub ahead of print] PubMed PMID: 27313175.
  • 5: Mossanen JC, Krenkel O, Ergen C, Govaere O, Liepelt A, Puengel T, Heymann F, Kalthoff S, Lefebvre E, Eulberg D, Luedde T, Marx G, Strassburg CP, Roskams T, Trautwein C, Tacke F. CCR2+ monocytes aggravate the early phase of acetaminophen induced acute liver injury. Hepatology. 2016 Jun 15. doi: 10.1002/hep.28682. [Epub ahead of print] PubMed PMID: 27302828.
  • 6: Weiskirchen R, Tacke F. Liver Fibrosis: From Pathogenesis to Novel Therapies. Dig Dis. 2016;34(4):410-22. doi: 10.1159/000444556. Epub 2016 May 11. PubMed PMID: 27170396.
  • 7: Roy S, Benz F, Alder J, Bantel H, Janssen J, Vucur M, Gautheron J, Schneider A, Schüller F, Loosen S, Luedde M, Koch A, Tacke F, Luedde T, Trautwein C, Roderburg C. Down-regulation of miR-192-5p protects from oxidative stress-induced acute liver injury. Clin Sci (Lond). 2016 Jul 1;130(14):1197-207. doi: 10.1042/CS20160216. Epub 2016 Apr 18. PubMed PMID: 27129188.
  • 8: Roderburg C, Benz F, Schüller F, Pombeiro I, Hippe HJ, Frey N, Trautwein C, Luedde T, Koch A, Tacke F, Luedde M. Serum Levels of TNF Receptor Ligands Are Dysregulated in Sepsis and Predict Mortality in Critically Ill Patients. PLoS One. 2016 Apr 28;11(4):e0153765. doi: 10.1371/journal.pone.0153765. eCollection 2016. PubMed PMID: 27124414; PubMed Central PMCID: PMC4849634.
  • 9: Tacke F, Kroy DC, Barreiros AP, Neumann UP. Liver transplantation in Germany. Liver Transpl. 2016 Apr 15. doi: 10.1002/lt.24461. [Epub ahead of print] Review. PubMed PMID: 27082951.
  • 10: Wiener A, Schippers A, Wagner N, Tacke F, Ostendorf T, Honke N, Tenbrock K, Ohl K. CXCR5 is critically involved in progression of lupus through regulation of B cell and double-negative T cell trafficking. Clin Exp Immunol. 2016 Jul;185(1):22-32. doi: 10.1111/cei.12791. Epub 2016 Apr 18. PubMed PMID: 26990531; PubMed Central PMCID: PMC4908294.
  • 11: Hartmann P, Tacke F. Tiny RNA with great effects: miR-155 in alcoholic liver disease. J Hepatol. 2016 Jun;64(6):1214-6. doi: 10.1016/j.jhep.2016.02.039. Epub 2016 Mar 3. PubMed PMID: 26948494.
  • 12: Schon HT, Bartneck M, Borkham-Kamphorst E, Nattermann J, Lammers T, Tacke F, Weiskirchen R. Pharmacological Intervention in Hepatic Stellate Cell Activation and Hepatic Fibrosis. Front Pharmacol. 2016 Feb 24;7:33. doi: 10.3389/fphar.2016.00033. eCollection 2016. Review. PubMed PMID: 26941644; PubMed Central PMCID: PMC4764688.
  • 13: Tacke F, Nuraldeen R, Koch A, Strathmann K, Hutschenreuter G, Trautwein C, Strnad P. Iron Parameters Determine the Prognosis of Critically Ill Patients. Crit Care Med. 2016 Jun;44(6):1049-58. doi: 10.1097/CCM.0000000000001607. PubMed PMID: 26934143.
  • 14: Ju C, Tacke F. Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies. Cell Mol Immunol. 2016 May;13(3):316-27. doi: 10.1038/cmi.2015.104. Epub 2016 Feb 24. PubMed PMID: 26908374; PubMed Central PMCID: PMC4856798.
  • 15: Buendgens L, Koch A, Tacke F. Prevention of stress-related ulcer bleeding at the intensive care unit: Risks and benefits of stress ulcer prophylaxis. World J Crit Care Med. 2016 Feb 4;5(1):57-64. doi: 10.5492/wjccm.v5.i1.57. eCollection 2016 Feb 4. Review. PubMed PMID: 26855894; PubMed Central PMCID: PMC4733456.
  • 16: Noll J, Helk E, Fehling H, Bernin H, Marggraff C, Jacobs T, Huber S, Pelczar P, Ernst T, Ittrich H, Otto B, Mittrücker HW, Hölscher C, Tacke F, Bruchhaus I, Tannich E, Lotter H. IL-23 prevents IL-13-dependent tissue repair associated with Ly6C(lo) monocytes in Entamoeba histolytica-induced liver damage. J Hepatol. 2016 May;64(5):1147-57. doi: 10.1016/j.jhep.2016.01.013. Epub 2016 Jan 22. PubMed PMID: 26809113.
  • 17: Heymann F, Tacke F. Immunology in the liver--from homeostasis to disease. Nat Rev Gastroenterol Hepatol. 2016 Feb;13(2):88-110. doi: 10.1038/nrgastro.2015.200. Epub 2016 Jan 13. Review. PubMed PMID: 26758786.
  • 18: Bartneck M, Fech V, Ehling J, Govaere O, Warzecha KT, Hittatiya K, Vucur M, Gautheron J, Luedde T, Trautwein C, Lammers T, Roskams T, Jahnen-Dechent W, Tacke F. Histidine-rich glycoprotein promotes macrophage activation and inflammation in chronic liver disease. Hepatology. 2016 Apr;63(4):1310-24. doi: 10.1002/hep.28418. Epub 2016 Feb 19. PubMed PMID: 26699087.
  • 19: Nevzorova YA, Cubero FJ, Hu W, Hao F, Haas U, Ramadori P, Gassler N, Hoss M, Strnad P, Zimmermann HW, Tacke F, Trautwein C, Liedtke C. Enhanced expression of c-myc in hepatocytes promotes initiation and progression of alcoholic liver disease. J Hepatol. 2016 Mar;64(3):628-40. doi: 10.1016/j.jhep.2015.11.005. Epub 2015 Nov 11. PubMed PMID: 26576483.
  • 20: Van Overmeire E, Stijlemans B, Heymann F, Keirsse J, Morias Y, Elkrim Y, Brys L, Abels C, Lahmar Q, Ergen C, Vereecke L, Tacke F, De Baetselier P, Van Ginderachter JA, Laoui D. M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment. Cancer Res. 2016 Jan 1;76(1):35-42. doi: 10.1158/0008-5472.CAN-15-0869. Epub 2015 Nov 16. PubMed PMID: 26573801.
  • 21: Tacke F, Wynn TA. Biomarker and Therapeutic Potential of CSF1 in Acute Liver Failure. Gastroenterology. 2015 Dec;149(7):1675-8. doi: 10.1053/j.gastro.2015.10.024. Epub 2015 Oct 23. PubMed PMID: 26505816.
  • 22: Shirvani-Dastgerdi E, Pourkarim MR, Herbers U, Amini-Bavil-Olyaee S, Yagmur E, Alavian SM, Trautwein C, Tacke F. Hepatitis delta virus facilitates the selection of hepatitis B virus mutants in vivo and functionally impacts on their replicative capacity in vitro. Clin Microbiol Infect. 2016 Jan;22(1):98.e1-6. doi: 10.1016/j.cmi.2015.09.020. Epub 2015 Oct 30. PubMed PMID: 26433026.
  • 23: Schneider AT, Gautheron J, Tacke F, Vucur M, Luedde T. Receptor interacting protein kinase 1 (RIPK1) in hepatocytes does not mediate murine acetaminophen toxicity. Hepatology. 2016 Jul;64(1):306-8. doi: 10.1002/hep.28225. Epub 2015 Dec 18. PubMed PMID: 26389825.
  • 24: Mina T, Amini-Bavil-Olyaee S, Dekervel J, Verslype C, Nevens F, Maes P, Tacke F, Van Ranst M, Pourkarim MR. A rare case of HBV genotype fluctuation (shifting and reversion) after liver transplantation. J Clin Virol. 2015 Oct;71:93-7. doi: 10.1016/j.jcv.2015.08.010. Epub 2015 Aug 21. PubMed PMID: 26342803.
  • 25: Hammerich L, Tacke F. Emerging roles of myeloid derived suppressor cells in hepatic inflammation and fibrosis. World J Gastrointest Pathophysiol. 2015 Aug 15;6(3):43-50. doi: 10.4291/wjgp.v6.i3.43. PubMed PMID: 26301117; PubMed Central PMCID: PMC4540705.
  • 26: Mina T, Amini Bavil Olyaee S, Tacke F, Maes P, Van Ranst M, Pourkarim MR. Genomic Diversity of Hepatitis B Virus Infection Associated With Fulminant Hepatitis B Development. Hepat Mon. 2015 Jun 23;15(6):e29477. doi: 10.5812/hepatmon.29477v2. eCollection 2015 Jun. Review. PubMed PMID: 26288637; PubMed Central PMCID: PMC4533131.
  • 27: Schierwagen R, Maybüchen L, Zimmer S, Hittatiya K, Bäck C, Klein S, Uschner FE, Reul W, Boor P, Nickenig G, Strassburg CP, Trautwein C, Plat J, Lütjohann D, Sauerbruch T, Tacke F, Trebicka J. Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis. Sci Rep. 2015 Aug 11;5:12931. doi: 10.1038/srep12931. PubMed PMID: 26263022; PubMed Central PMCID: PMC4531783.
  • 28: Bartneck M, Warzecha KT, Tag CG, Sauer-Lehnen S, Heymann F, Trautwein C, Weiskirchen R, Tacke F. Isolation and time lapse microscopy of highly pure hepatic stellate cells. Anal Cell Pathol (Amst). 2015;2015:417023. doi: 10.1155/2015/417023. Epub 2015 Jul 16. PubMed PMID: 26258009; PubMed Central PMCID: PMC4519541.
  • 29: Kahles F, Meyer C, Möllmann J, Diebold S, Findeisen HM, Lebherz C, Trautwein C, Koch A, Tacke F, Marx N, Lehrke M. [IL-6 dependent GLP-1 secretion during acute inflammation]. Med Klin Intensivmed Notfmed. 2015 Sep;110(6):462-4. doi: 10.1007/s00063-015-0059-2. German. PubMed PMID: 26250691.
  • 30: Tacke F, Trautwein C. Mechanisms of liver fibrosis resolution. J Hepatol. 2015 Oct;63(4):1038-9. doi: 10.1016/j.jhep.2015.03.039. Epub 2015 Jul 29. PubMed PMID: 26232376.
  • 31: Schneider KM, Bieghs V, Heymann F, Hu W, Dreymueller D, Liao L, Frissen M, Ludwig A, Gassler N, Pabst O, Latz E, Sellge G, Penders J, Tacke F, Trautwein C. CX3CR1 is a gatekeeper for intestinal barrier integrity in mice: Limiting steatohepatitis by maintaining intestinal homeostasis. Hepatology. 2015 Nov;62(5):1405-16. doi: 10.1002/hep.27982. Epub 2015 Sep 2. PubMed PMID: 26178698.
  • 32: Roeb E, Steffen HM, Bantel H, Baumann U, Canbay A, Demir M, Drebber U, Geier A, Hampe J, Hellerbrand C, Pathil-Warth A, Schattenberg JM, Schramm C, Seitz HK, Stefan N, Tacke F, Tannapfel A, Lynen Jansen P, Bojunga J. [S2k Guideline non-alcoholic fatty liver disease]. Z Gastroenterol. 2015 Jul;53(7):668-723. doi: 10.1055/s-0035-1553193. Epub 2015 Jul 13. German. PubMed PMID: 26167698.
  • 33: Zimmermann HW, Tacke F. In search of the magic bullet: can liver inflammation and fibrosis be reversed with medications? Expert Rev Gastroenterol Hepatol. 2015;9(9):1139-41. doi: 10.1586/17474124.2015.1063417. Epub 2015 Jul 9. Review. PubMed PMID: 26138749.
  • 34: Ehling J, Tacke F. Role of chemokine pathways in hepatobiliary cancer. Cancer Lett. 2015 Jun 26. pii: S0304-3835(15)00411-5. doi: 10.1016/j.canlet.2015.06.017. [Epub ahead of print] PubMed PMID: 26123664.
  • 35: Roy S, Benz F, Vargas Cardenas D, Vucur M, Gautheron J, Schneider A, Hellerbrand C, Pottier N, Alder J, Tacke F, Trautwein C, Roderburg C, Luedde T. miR-30c and miR-193 are a part of the TGF-β-dependent regulatory network controlling extracellular matrix genes in liver fibrosis. J Dig Dis. 2015 Sep;16(9):513-24. doi: 10.1111/1751-2980.12266. PubMed PMID: 26120970.
  • 36: Roderburg C, Benz F, Cardenas DV, Lutz M, Hippe HJ, Luedde T, Trautwein C, Frey N, Koch A, Tacke F, Luedde M. Persistently elevated osteopontin serum levels predict mortality in critically ill patients. Crit Care. 2015 Jun 26;19:271. doi: 10.1186/s13054-015-0988-4. PubMed PMID: 26111529; PubMed Central PMCID: PMC4490692.
  • 37: Weiss J, Rau M, Bantel H, Bock H, Demir M, Kluwe J, Krawczyk M, Pathil-Warth A, Schattenberg JM, Tacke F, Roeb E, Geier A; Klinische Studiengruppe NAFLD (NAFLD CSG):. [First data concerning the medical supply of patients with non-alcoholic fatty liver disease in Germany - a survey in university hospital centers of hepatology]. Z Gastroenterol. 2015 Jun;53(6):562-7. doi: 10.1055/s-0034-1399180. Epub 2015 Jun 15. German. PubMed PMID: 26079073.
  • 38: Asimakopoulou A, Borkham-Kamphorst E, Tacke F, Weiskirchen R. Lipocalin-2 (NGAL/LCN2), a "help-me" signal in organ inflammation. Hepatology. 2016 Feb;63(2):669-71. doi: 10.1002/hep.27930. Epub 2015 Jul 31. PubMed PMID: 26054053.
  • 39: Liepelt A, Tacke F. Healing the scars of life-targeting redox imbalance in fibrotic disorders of the elderly. Ann Transl Med. 2015 May;3(Suppl 1):S13. doi: 10.3978/j.issn.2305-5839.2015.03.34. PubMed PMID: 26046058; PubMed Central PMCID: PMC4437926.
  • 40: Weiskirchen R, Tacke F. Small heterodimer partner (SHP) links hepatitis C and liver fibrosis: a small protein on the big stage. Liver Int. 2015 Oct;35(10):2218-21. doi: 10.1111/liv.12881. PubMed PMID: 26037155.
  • 41: Morias Y, Abels C, Laoui D, Van Overmeire E, Guilliams M, Schouppe E, Tacke F, deVries CJ, De Baetselier P, Beschin A. Ly6C- Monocytes Regulate Parasite-Induced Liver Inflammation by Inducing the Differentiation of Pathogenic Ly6C+ Monocytes into Macrophages. PLoS Pathog. 2015 May 28;11(5):e1004873. doi: 10.1371/journal.ppat.1004873. eCollection 2015 May. PubMed PMID: 26020782; PubMed Central PMCID: PMC4447383.
  • 42: Shirvani-Dastgerdi E, Tacke F. Molecular interactions between hepatitis B virus and delta virus. World J Virol. 2015 May 12;4(2):36-41. doi: 10.5501/wjv.v4.i2.36. PubMed PMID: 25964870; PubMed Central PMCID: PMC4419120.
  • 43: Heymann F, Niemietz PM, Peusquens J, Ergen C, Kohlhepp M, Mossanen JC, Schneider C, Vogt M, Tolba RH, Trautwein C, Martin C, Tacke F. Long term intravital multiphoton microscopy imaging of immune cells in healthy and diseased liver using CXCR6.Gfp reporter mice. J Vis Exp. 2015 Mar 24;(97). doi: 10.3791/52607. PubMed PMID: 25866988.
  • 44: Bartneck M, Topuz F, Tag CG, Sauer-Lehnen S, Warzecha KT, Trautwein C, Weiskirchen R, Tacke F. Molecular response of liver sinusoidal endothelial cells on hydrogels. Mater Sci Eng C Mater Biol Appl. 2015 Jun;51:64-72. doi: 10.1016/j.msec.2015.02.045. Epub 2015 Feb 26. PubMed PMID: 25842109.
  • 45: Tag CG, Weiskirchen S, Hittatiya K, Tacke F, Tolba RH, Weiskirchen R. Induction of experimental obstructive cholestasis in mice. Lab Anim. 2015 Apr;49(1 Suppl):70-80. doi: 10.1177/0023677214567748. PubMed PMID: 25835740.
  • 46: Mossanen JC, Tacke F. Acetaminophen-induced acute liver injury in mice. Lab Anim. 2015 Apr;49(1 Suppl):30-6. doi: 10.1177/0023677215570992. PubMed PMID: 25835736.
  • 47: Heymann F, Hamesch K, Weiskirchen R, Tacke F. The concanavalin A model of acute hepatitis in mice. Lab Anim. 2015 Apr;49(1 Suppl):12-20. doi: 10.1177/0023677215572841. PubMed PMID: 25835734.
  • 48: Benz F, Tacke F, Luedde M, Trautwein C, Luedde T, Koch A, Roderburg C. Circulating microRNA-223 serum levels do not predict sepsis or survival in patients with critical illness. Dis Markers. 2015;2015:384208. doi: 10.1155/2015/384208. Epub 2015 Feb 24. PubMed PMID: 25810564; PubMed Central PMCID: PMC4355123.
  • 49: Heymann F, Peusquens J, Ludwig-Portugall I, Kohlhepp M, Ergen C, Niemietz P, Martin C, van Rooijen N, Ochando JC, Randolph GJ, Luedde T, Ginhoux F, Kurts C, Trautwein C, Tacke F. Liver inflammation abrogates immunological tolerance induced by Kupffer cells. Hepatology. 2015 Jul;62(1):279-91. doi: 10.1002/hep.27793. Epub 2015 Apr 22. PubMed PMID: 25810240.
  • 50: Brix SR, Stege G, Disteldorf E, Hoxha E, Krebs C, Krohn S, Otto B, Klätschke K, Herden E, Heymann F, Lira SA, Tacke F, Wolf G, Busch M, Jabs WJ, Özcan F, Keller F, Beige J, Wagner K, Helmchen U, Noriega M, Wiech T, Panzer U, Stahl RA. CC Chemokine Ligand 18 in ANCA-Associated Crescentic GN. J Am Soc Nephrol. 2015 Sep;26(9):2105-17. doi: 10.1681/ASN.2014040407. Epub 2015 Mar 11. PubMed PMID: 25762060; PubMed Central PMCID: PMC4552107.
  • 51: Tag CG, Sauer-Lehnen S, Weiskirchen S, Borkham-Kamphorst E, Tolba RH, Tacke F, Weiskirchen R. Bile duct ligation in mice: induction of inflammatory liver injury and fibrosis by obstructive cholestasis. J Vis Exp. 2015 Feb 10;(96). doi: 10.3791/52438. PubMed PMID: 25741630; PubMed Central PMCID: PMC4354634.
  • 52: Höchst B, Mikulec J, Baccega T, Metzger C, Welz M, Peusquens J, Tacke F, Knolle P, Kurts C, Diehl L, Ludwig-Portugall I. Differential induction of Ly6G and Ly6C positive myeloid derived suppressor cells in chronic kidney and liver inflammation and fibrosis. PLoS One. 2015 Mar 4;10(3):e0119662. doi: 10.1371/journal.pone.0119662. eCollection 2015. PubMed PMID: 25738302; PubMed Central PMCID: PMC4349817.
  • 53: Shirvani-Dastgerdi E, Amini-Bavil-Olyaee S, Alavian SM, Trautwein C, Tacke F. Comprehensive analysis of mutations in the hepatitis delta virus genome based on full-length sequencing in a nationwide cohort study and evolutionary pattern during disease progression. Clin Microbiol Infect. 2015 May;21(5):510.e11-23. doi: 10.1016/j.cmi.2014.12.008. Epub 2014 Dec 26. PubMed PMID: 25656625.
  • 54: Bartneck M, Warzecha KT, Tacke F. Therapeutic targeting of liver inflammation and fibrosis by nanomedicine. Hepatobiliary Surg Nutr. 2014 Dec;3(6):364-76. doi: 10.3978/j.issn.2304-3881.2014.11.02. Review. PubMed PMID: 25568860; PubMed Central PMCID: PMC4273112.
  • 55: Weiskirchen R, Tacke F. Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology. Hepatobiliary Surg Nutr. 2014 Dec;3(6):344-63. doi: 10.3978/j.issn.2304-3881.2014.11.03. Review. PubMed PMID: 25568859; PubMed Central PMCID: PMC4273119.
  • 56: Krenkel O, Mossanen JC, Tacke F. Immune mechanisms in acetaminophen-induced acute liver failure. Hepatobiliary Surg Nutr. 2014 Dec;3(6):331-43. doi: 10.3978/j.issn.2304-3881.2014.11.01. Review. PubMed PMID: 25568858; PubMed Central PMCID: PMC4273118.
  • 57: Tacke F. Reply: To PMID 24481979. Gastroenterology. 2014 Dec;147(6):1431. PubMed PMID: 25457849.
  • 58: Berres ML, Asmacher S, Lehmann J, Jansen C, Görtzen J, Klein S, Meyer C, Strunk HM, Fimmers R, Tacke F, Strassburg CP, Trautwein C, Sauerbruch T, Wasmuth HE, Trebicka J. CXCL9 is a prognostic marker in patients with liver cirrhosis receiving transjugular intrahepatic portosystemic shunt. J Hepatol. 2015 Feb;62(2):332-9. doi: 10.1016/j.jhep.2014.09.032. Epub 2014 Oct 17. PubMed PMID: 25457205.
  • 59: Bartneck M, Scheyda KM, Warzecha KT, Rizzo LY, Hittatiya K, Luedde T, Storm G, Trautwein C, Lammers T, Tacke F. Fluorescent cell-traceable dexamethasone-loaded liposomes for the treatment of inflammatory liver diseases. Biomaterials. 2015 Jan;37:367-82. doi: 10.1016/j.biomaterials.2014.10.030. Epub 2014 Oct 26. PubMed PMID: 25453965.
  • 60: Koch A, Tacke F. Variceal bleeding in liver cirrhosis at the ICU: sufficient data to treat adrenal insufficiency?*. Crit Care Med. 2014 Dec;42(12):2639-40. doi: 10.1097/CCM.0000000000000598. PubMed PMID: 25402288.
  • 61: Wehr A, Baeck C, Ulmer F, Gassler N, Hittatiya K, Luedde T, Neumann UP, Trautwein C, Tacke F. Pharmacological inhibition of the chemokine CXCL16 diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. PLoS One. 2014 Nov 5;9(11):e112327. doi: 10.1371/journal.pone.0112327. eCollection 2014. PubMed PMID: 25372401; PubMed Central PMCID: PMC4221470.
  • 62: Hammerich L, Warzecha KT, Stefkova M, Bartneck M, Ohl K, Gassler N, Luedde T, Trautwein C, Tenbrock K, Tacke F. Cyclic adenosine monophosphate-responsive element modulator alpha overexpression impairs function of hepatic myeloid-derived suppressor cells and aggravates immune-mediated hepatitis in mice. Hepatology. 2015 Mar;61(3):990-1002. doi: 10.1002/hep.27571. Epub 2015 Jan 30. PubMed PMID: 25330465.
  • 63: Frehn L, Jansen A, Bennek E, Mandic AD, Temizel I, Tischendorf S, Verdier J, Tacke F, Streetz K, Trautwein C, Sellge G. Distinct patterns of IgG and IgA against food and microbial antigens in serum and feces of patients with inflammatory bowel diseases. PLoS One. 2014 Sep 12;9(9):e106750. doi: 10.1371/journal.pone.0106750. eCollection 2014. PubMed PMID: 25215528; PubMed Central PMCID: PMC4162554.
  • 64: Hammerich L, Tacke F. Interleukins in chronic liver disease: lessons learned from experimental mouse models. Clin Exp Gastroenterol. 2014 Sep 1;7:297-306. doi: 10.2147/CEG.S43737. eCollection 2014. Review. PubMed PMID: 25214799; PubMed Central PMCID: PMC4158890.
  • 65: Marra F, Tacke F. Roles for chemokines in liver disease. Gastroenterology. 2014 Sep;147(3):577-594.e1. doi: 10.1053/j.gastro.2014.06.043. Epub 2014 Jul 25. Review. PubMed PMID: 25066692.
  • 66: Roderburg C, Benz F, Vargas Cardenas D, Koch A, Janssen J, Vucur M, Gautheron J, Schneider AT, Koppe C, Kreggenwinkel K, Zimmermann HW, Luedde M, Trautwein C, Tacke F, Luedde T. Elevated miR-122 serum levels are an independent marker of liver injury in inflammatory diseases. Liver Int. 2015 Apr;35(4):1172-84. doi: 10.1111/liv.12627. Epub 2014 Jul 21. PubMed PMID: 25039534.
  • 67: Gautheron J, Vucur M, Reisinger F, Cardenas DV, Roderburg C, Koppe C, Kreggenwinkel K, Schneider AT, Bartneck M, Neumann UP, Canbay A, Reeves HL, Luedde M, Tacke F, Trautwein C, Heikenwalder M, Luedde T. A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis. EMBO Mol Med. 2014 Jun 24;6(8):1062-74. doi: 10.15252/emmm.201403856. PubMed PMID: 24963148; PubMed Central PMCID: PMC4154133.
  • 68: Kahles F, Meyer C, Möllmann J, Diebold S, Findeisen HM, Lebherz C, Trautwein C, Koch A, Tacke F, Marx N, Lehrke M. GLP-1 secretion is increased by inflammatory stimuli in an IL-6-dependent manner, leading to hyperinsulinemia and blood glucose lowering. Diabetes. 2014 Oct;63(10):3221-9. doi: 10.2337/db14-0100. Epub 2014 Jun 19. PubMed PMID: 24947356.
  • 69: Hammerich L, Tacke F. Role of gamma-delta T cells in liver inflammation and fibrosis. World J Gastrointest Pathophysiol. 2014 May 15;5(2):107-13. doi: 10.4291/wjgp.v5.i2.107. Review. PubMed PMID: 24891982; PubMed Central PMCID: PMC4025070.
  • 70: Liepelt A, Mossanen JC, Denecke B, Heymann F, De Santis R, Tacke F, Marx G, Ostareck DH, Ostareck-Lederer A. Translation control of TAK1 mRNA by hnRNP K modulates LPS-induced macrophage activation. RNA. 2014 Jun;20(6):899-911. doi: 10.1261/rna.042788.113. Epub 2014 Apr 21. PubMed PMID: 24751651; PubMed Central PMCID: PMC4024643.
  • 71: Buendgens L, Bruensing J, Matthes M, Dückers H, Luedde T, Trautwein C, Tacke F, Koch A. Administration of proton pump inhibitors in critically ill medical patients is associated with increased risk of developing Clostridium difficile-associated diarrhea. J Crit Care. 2014 Aug;29(4):696.e11-5. doi: 10.1016/j.jcrc.2014.03.002. Epub 2014 Mar 7. PubMed PMID: 24674763.
  • 72: Bartneck M, Peters FM, Warzecha KT, Bienert M, van Bloois L, Trautwein C, Lammers T, Tacke F. Liposomal encapsulation of dexamethasone modulates cytotoxicity, inflammatory cytokine response, and migratory properties of primary human macrophages. Nanomedicine. 2014 Aug;10(6):1209-20. doi: 10.1016/j.nano.2014.02.011. Epub 2014 Mar 7. PubMed PMID: 24607939.
  • 73: Koch A, Zimmermann HW, Gassler N, Jochum C, Weiskirchen R, Bruensing J, Buendgens L, Dückers H, Bruns T, Gerken G, Neumann UP, Adams DH, Trautwein C, Canbay A, Tacke F. Clinical relevance and cellular source of elevated soluble urokinase plasminogen activator receptor (suPAR) in acute liver failure. Liver Int. 2014 Oct;34(9):1330-9. doi: 10.1111/liv.12512. Epub 2014 Mar 19. PubMed PMID: 24575897.
  • 74: Hammerich L, Tacke F. Eat more carrots? Dampening cell death in ethanol-induced liver fibrosis by β-carotene. Hepatobiliary Surg Nutr. 2013 Oct;2(5):248-51. doi: 10.3978/j.issn.2304-3881.2013.10.03. PubMed PMID: 24570954; PubMed Central PMCID: PMC3924691.
  • 75: Ehling J, Bartneck M, Wei X, Gremse F, Fech V, Möckel D, Baeck C, Hittatiya K, Eulberg D, Luedde T, Kiessling F, Trautwein C, Lammers T, Tacke F. CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis. Gut. 2014 Dec;63(12):1960-71. doi: 10.1136/gutjnl-2013-306294. Epub 2014 Feb 21. PubMed PMID: 24561613; PubMed Central PMCID: PMC4216733.
  • 76: Mossanen JC, Tacke F. Role of lymphocytes in liver cancer. Oncoimmunology. 2013 Nov 1;2(11):e26468. Epub 2013 Oct 21. Review. PubMed PMID: 24498546; PubMed Central PMCID: PMC3906418.
  • 77: Baeck C, Wei X, Bartneck M, Fech V, Heymann F, Gassler N, Hittatiya K, Eulberg D, Luedde T, Trautwein C, Tacke F. Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C(+) macrophage infiltration in mice. Hepatology. 2014 Mar;59(3):1060-72. doi: 10.1002/hep.26783. Epub 2014 Jan 30. PubMed PMID: 24481979.
  • 78: Tacke F, Roderburg C, Benz F, Cardenas DV, Luedde M, Hippe HJ, Frey N, Vucur M, Gautheron J, Koch A, Trautwein C, Luedde T. Levels of circulating miR-133a are elevated in sepsis and predict mortality in critically ill patients. Crit Care Med. 2014 May;42(5):1096-104. doi: 10.1097/CCM.0000000000000131. PubMed PMID: 24413579.
  • 79: Tacke F, Zimmermann HW. Macrophage heterogeneity in liver injury and fibrosis. J Hepatol. 2014 May;60(5):1090-6. doi: 10.1016/j.jhep.2013.12.025. Epub 2014 Jan 8. Review. PubMed PMID: 24412603.
  • 80: Baeck C, Tacke F. Balance of inflammatory pathways and interplay of immune cells in the liver during homeostasis and injury. EXCLI J. 2014 Feb 7;13:67-81. eCollection 2014. Review. PubMed PMID: 26417243; PubMed Central PMCID: PMC4464465.
  • 81: Streetz KL, Tacke F, Koch A, Trautwein C. [Acute liver failure. Diagnosis and therapy]. Med Klin Intensivmed Notfmed. 2013 Nov;108(8):639-45. doi: 10.1007/s00063-013-0285-4. Epub 2013 Nov 6. Review. German. PubMed PMID: 24189846.
  • 82: Koch A, Streetz K, Tischendorf J, Trautwein C, Tacke F. [Abnormal liver function tests in the intensive care unit]. Med Klin Intensivmed Notfmed. 2013 Oct;108(7):599-608; quiz 609-10. doi: 10.1007/s00063-013-0287-2. Review. German. PubMed PMID: 24145708.
  • 83: Benz F, Roderburg C, Vargas Cardenas D, Vucur M, Gautheron J, Koch A, Zimmermann H, Janssen J, Nieuwenhuijsen L, Luedde M, Frey N, Tacke F, Trautwein C, Luedde T. U6 is unsuitable for normalization of serum miRNA levels in patients with sepsis or liver fibrosis. Exp Mol Med. 2013 Sep 20;45:e42. doi: 10.1038/emm.2013.81. PubMed PMID: 24052167; PubMed Central PMCID: PMC3789266.
  • 84: Lerschmacher O, Koch A, Streetz K, Trautwein C, Tacke F. [Management of decompensated liver cirrhosis in the intensive care unit]. Med Klin Intensivmed Notfmed. 2013 Nov;108(8):646-56. doi: 10.1007/s00063-013-0259-6. Epub 2013 Sep 14. Review. German. PubMed PMID: 24030843.
  • 85: Vucur M, Reisinger F, Gautheron J, Janssen J, Roderburg C, Cardenas DV, Kreggenwinkel K, Koppe C, Hammerich L, Hakem R, Unger K, Weber A, Gassler N, Luedde M, Frey N, Neumann UP, Tacke F, Trautwein C, Heikenwalder M, Luedde T. RIP3 inhibits inflammatory hepatocarcinogenesis but promotes cholestasis by controlling caspase-8- and JNK-dependent compensatory cell proliferation. Cell Rep. 2013 Aug 29;4(4):776-90. doi: 10.1016/j.celrep.2013.07.035. Epub 2013 Aug 22. PubMed PMID: 23972991.
  • 86: Hammerich L, Bangen JM, Govaere O, Zimmermann HW, Gassler N, Huss S, Liedtke C, Prinz I, Lira SA, Luedde T, Roskams T, Trautwein C, Heymann F, Tacke F. Chemokine receptor CCR6-dependent accumulation of γδ T cells in injured liver restricts hepatic inflammation and fibrosis. Hepatology. 2014 Feb;59(2):630-42. doi: 10.1002/hep.26697. Epub 2013 Dec 23. PubMed PMID: 23959575; PubMed Central PMCID: PMC4139146.
  • 87: Koch A, Weiskirchen R, Kunze J, Dückers H, Bruensing J, Buendgens L, Matthes M, Luedde T, Trautwein C, Tacke F. Elevated asymmetric dimethylarginine levels predict short- and long-term mortality risk in critically ill patients. J Crit Care. 2013 Dec;28(6):947-53. doi: 10.1016/j.jcrc.2013.05.016. Epub 2013 Aug 14. PubMed PMID: 23953490.
  • 88: Koch A, Weiskirchen R, Bruensing J, Dückers H, Buendgens L, Kunze J, Matthes M, Luedde T, Trautwein C, Tacke F. Regulation and prognostic relevance of symmetric dimethylarginine serum concentrations in critical illness and sepsis. Mediators Inflamm. 2013;2013:413826. doi: 10.1155/2013/413826. Epub 2013 Jun 27. PubMed PMID: 23935249; PubMed Central PMCID: PMC3712234.
  • 89: Hanssen L, Alidousty C, Djudjaj S, Frye BC, Rauen T, Boor P, Mertens PR, van Roeyen CR, Tacke F, Heymann F, Tittel AP, Koch A, Floege J, Ostendorf T, Raffetseder U. YB-1 is an early and central mediator of bacterial and sterile inflammation in vivo. J Immunol. 2013 Sep 1;191(5):2604-13. doi: 10.4049/jimmunol.1300416. Epub 2013 Jul 19. PubMed PMID: 23872051.
  • 90: Zimmermann HW, Mueller JR, Seidler S, Luedde T, Trautwein C, Tacke F. Frequency and phenotype of human circulating and intrahepatic natural killer cell subsets is differentially regulated according to stage of chronic liver disease. Digestion. 2013;88(1):1-16. doi: 10.1159/000350821. Epub 2013 Jun 14. PubMed PMID: 23774822.
  • 91: Nevzorova YA, Hu W, Cubero FJ, Haas U, Freimuth J, Tacke F, Trautwein C, Liedtke C. Overexpression of c-myc in hepatocytes promotes activation of hepatic stellate cells and facilitates the onset of liver fibrosis. Biochim Biophys Acta. 2013 Oct;1832(10):1765-75. doi: 10.1016/j.bbadis.2013.06.001. Epub 2013 Jun 12. PubMed PMID: 23770341.
  • 92: Wehr A, Baeck C, Heymann F, Niemietz PM, Hammerich L, Martin C, Zimmermann HW, Pack O, Gassler N, Hittatiya K, Ludwig A, Luedde T, Trautwein C, Tacke F. Chemokine receptor CXCR6-dependent hepatic NK T Cell accumulation promotes inflammation and liver fibrosis. J Immunol. 2013 May 15;190(10):5226-36. doi: 10.4049/jimmunol.1202909. Epub 2013 Apr 17. PubMed PMID: 23596313.
  • 93: Stock MK, Hammerich L, do O NT, Berres ML, Alsamman M, Heinrichs D, Nellen A, Trautwein C, Tacke F, Wasmuth HE, Sahin H. Met-CCL5 modifies monocyte subpopulations during liver fibrosis regression. Int J Clin Exp Pathol. 2013;6(4):678-85. Epub 2013 Mar 15. PubMed PMID: 23573314; PubMed Central PMCID: PMC3606857.
  • 94: Koch A, Buendgens L, Dückers H, Bruensing J, Matthes M, Kunze J, Lutz HH, Luedde T, Tischendorf JJ, Trautwein C, Tacke F. [Bleeding origin, patient-related risk factors, and prognostic indicators in patients with acute gastrointestinal hemorrhages requiring intensive care treatment. A retrospective analysis from 1999 to 2010]. Med Klin Intensivmed Notfmed. 2013 Apr;108(3):214-22. doi: 10.1007/s00063-013-0226-2. Epub 2013 Mar 17. German. PubMed PMID: 23503668.
  • 95: Zimmermann HW, Reuken PA, Koch A, Bartneck M, Adams DH, Trautwein C, Stallmach A, Tacke F, Bruns T. Soluble urokinase plasminogen activator receptor is compartmentally regulated in decompensated cirrhosis and indicates immune activation and short-term mortality. J Intern Med. 2013 Jul;274(1):86-100. doi: 10.1111/joim.12054. Epub 2013 Mar 17. PubMed PMID: 23432143.
  • 96: Ehling J, Bartneck M, Fech V, Butzbach B, Cesati R, Botnar R, Lammers T, Tacke F. Elastin-based molecular MRI of liver fibrosis. Hepatology. 2013 Oct;58(4):1517-8. doi: 10.1002/hep.26326. PubMed PMID: 23424008.
  • 97: Borkham-Kamphorst E, van de Leur E, Zimmermann HW, Karlmark KR, Tihaa L, Haas U, Tacke F, Berger T, Mak TW, Weiskirchen R. Protective effects of lipocalin-2 (LCN2) in acute liver injury suggest a novel function in liver homeostasis. Biochim Biophys Acta. 2013 May;1832(5):660-73. doi: 10.1016/j.bbadis.2013.01.014. Epub 2013 Jan 31. PubMed PMID: 23376114.
  • 98: Roderburg C, Luedde M, Vargas Cardenas D, Vucur M, Scholten D, Frey N, Koch A, Trautwein C, Tacke F, Luedde T. Circulating microRNA-150 serum levels predict survival in patients with critical illness and sepsis. PLoS One. 2013;8(1):e54612. doi: 10.1371/journal.pone.0054612. Epub 2013 Jan 23. PubMed PMID: 23372743; PubMed Central PMCID: PMC3555785.
  • 99: Roderburg C, Koch A, Tacke F, Nieuwenhuijsen L, Bruensing J, Vargas Cardenas D, Kreggenwinkel K, Vucur M, Koppe C, Jungebluth P, Seikrit C, Luedde M, Trautwein C, Luedde T. Serum concentrations of A Proliferation-Inducing Ligand (APRIL) are elevated in sepsis and predict mortality in critically ill patients. J Crit Care. 2013 Oct;28(5):882.e1-11. doi: 10.1016/j.jcrc.2012.11.007. Epub 2013 Jan 20. PubMed PMID: 23337484.
  • 100: Koch A, Buendgens L, Dückers H, Bruensing J, Matthes M, Kunze J, Herbers U, Lutz HH, Luedde T, Tischendorf JJ, Trautwein C, Tacke F. [Gastrointestinal bleeding in liver cirrhosis at the ICU]. Z Gastroenterol. 2013 Jan;51(1):19-25. doi: 10.1055/s-0032-1330414. Epub 2013 Jan 11. German. PubMed PMID: 23315647.
  • 101: Herbers U, Amini-Bavil-Olyaee S, Mueller A, Luedde T, Trautwein C, Tacke F. Hepatitis B e antigen-suppressing mutations enhance the replication efficiency of adefovir-resistant hepatitis B virus strains. J Viral Hepat. 2013 Feb;20(2):141-8. doi: 10.1111/j.1365-2893.2012.01639.x. Epub 2012 Jul 3. PubMed PMID: 23301549.
  • 102: Tacke F. Functional role of intrahepatic monocyte subsets for the progression of liver inflammation and liver fibrosis in vivo. Fibrogenesis Tissue Repair. 2012 Jun 6;5(Suppl 1):S27. doi: 10.1186/1755-1536-5-S1-S27. eCollection 2012. PubMed PMID: 23259611; PubMed Central PMCID: PMC3368797.
  • 103: Roderburg C, Luedde M, Vargas Cardenas D, Vucur M, Mollnow T, Zimmermann HW, Koch A, Hellerbrand C, Weiskirchen R, Frey N, Tacke F, Trautwein C, Luedde T. miR-133a mediates TGF-β-dependent derepression of collagen synthesis in hepatic stellate cells during liver fibrosis. J Hepatol. 2013 Apr;58(4):736-42. doi: 10.1016/j.jhep.2012.11.022. Epub 2012 Nov 23. PubMed PMID: 23183523.
  • 104: Schneider C, Tacke F. Distinct anti-tumoral functions of adaptive immune cells in liver cancer. Oncoimmunology. 2012 Sep 1;1(6):937-939. PubMed PMID: 23162763; PubMed Central PMCID: PMC3489751.
  • 105: Seré K, Baek JH, Ober-Blöbaum J, Müller-Newen G, Tacke F, Yokota Y, Zenke M, Hieronymus T. Two distinct types of Langerhans cells populate the skin during steady state and inflammation. Immunity. 2012 Nov 16;37(5):905-16. doi: 10.1016/j.immuni.2012.07.019. PubMed PMID: 23159228.
  • 106: Zimmermann HW, Trautwein C, Tacke F. Functional role of monocytes and macrophages for the inflammatory response in acute liver injury. Front Physiol. 2012 Oct 19;3:56. doi: 10.3389/fphys.2012.00056. eCollection 2012. PubMed PMID: 23091461; PubMed Central PMCID: PMC3475871.
  • 107: Bartneck M, Ritz T, Keul HA, Wambach M, Bornemann J, Gbureck U, Ehling J, Lammers T, Heymann F, Gassler N, Lüdde T, Trautwein C, Groll J, Tacke F. Peptide-functionalized gold nanorods increase liver injury in hepatitis. ACS Nano. 2012 Oct 23;6(10):8767-77. doi: 10.1021/nn302502u. Epub 2012 Oct 1. PubMed PMID: 22994679.
  • 108: Borkham-Kamphorst E, Zimmermann HW, Gassler N, Bissels U, Bosio A, Tacke F, Weiskirchen R, Kanse SM. Factor VII activating protease (FSAP) exerts anti-inflammatory and anti-fibrotic effects in liver fibrosis in mice and men. J Hepatol. 2013 Jan;58(1):104-11. doi: 10.1016/j.jhep.2012.09.007. Epub 2012 Sep 16. Erratum in: J Hepatol. 2014 Oct;61(4):967. PubMed PMID: 22989567.
  • 109: Tacke F, Shirvani-Dastgerdi E. Impact of Drug-Resistance Polymerase Mutations on the Replication of HBeAg-Positive and HBeAg-Negative Hepatitis B Virus Strains in Vitro. Hepat Mon. 2012 Jun;12(6):357-60. doi: 10.5812/hepatmon.6131. Epub 2012 Jun 30. PubMed PMID: 22879823; PubMed Central PMCID: PMC3412550.
  • 110: Lutz HH, Wasmuth HE, Streetz K, Tacke F, Koch A, Luedde T, Trautwein C, Tischendorf JJ. Endoscopic ultrasound as an early diagnostic tool for primary sclerosing cholangitis: a prospective pilot study. Endoscopy. 2012 Oct;44(10):934-9. doi: 10.1055/s-0032-1309896. Epub 2012 Jul 2. PubMed PMID: 22752890.
  • 111: Dastgerdi ES, Herbers U, Tacke F. Molecular and clinical aspects of hepatitis D virus infections. World J Virol. 2012 Jun 12;1(3):71-8. doi: 10.5501/wjv.v1.i3.71. PubMed PMID: 24175212; PubMed Central PMCID: PMC3782269.
  • 112: Koch A, Tacke F, Streetz KL, Trautwein C. [Treatment of inflammatory bowel disease in intensive care medicine]. Dtsch Med Wochenschr. 2012 May;137(21):1107-18; quiz 19-20. doi: 10.1055/s-0032-1304963. Epub 2012 May 15. Review. German. PubMed PMID: 22588657.
  • 113: Kabgani N, Grigoleit T, Schulte K, Sechi A, Sauer-Lehnen S, Tag C, Boor P, Kuppe C, Warsow G, Schordan S, Mostertz J, Chilukoti RK, Homuth G, Endlich N, Tacke F, Weiskirchen R, Fuellen G, Endlich K, Floege J, Smeets B, Moeller MJ. Primary cultures of glomerular parietal epithelial cells or podocytes with proven origin. PLoS One. 2012;7(4):e34907. doi: 10.1371/journal.pone.0034907. Epub 2012 Apr 18. PubMed PMID: 22529955; PubMed Central PMCID: PMC3329559.
  • 114: Nevzorova YA, Bangen JM, Hu W, Haas U, Weiskirchen R, Gassler N, Huss S, Tacke F, Sicinski P, Trautwein C, Liedtke C. Cyclin E1 controls proliferation of hepatic stellate cells and is essential for liver fibrogenesis in mice. Hepatology. 2012 Sep;56(3):1140-9. doi: 10.1002/hep.25736. Epub 2012 Jul 12. PubMed PMID: 22454377; PubMed Central PMCID: PMC3396430.
  • 115: Roderburg C, Mollnow T, Bongaerts B, Elfimova N, Vargas Cardenas D, Berger K, Zimmermann H, Koch A, Vucur M, Luedde M, Hellerbrand C, Odenthal M, Trautwein C, Tacke F, Luedde T. Micro-RNA profiling in human serum reveals compartment-specific roles of miR-571 and miR-652 in liver cirrhosis. PLoS One. 2012;7(3):e32999. doi: 10.1371/journal.pone.0032999. Epub 2012 Mar 7. PubMed PMID: 22412969; PubMed Central PMCID: PMC3296762.
  • 116: Bartneck M, Keul HA, Wambach M, Bornemann J, Gbureck U, Chatain N, Neuss S, Tacke F, Groll J, Zwadlo-Klarwasser G. Effects of nanoparticle surface-coupled peptides, functional endgroups, and charge on intracellular distribution and functionality of human primary reticuloendothelial cells. Nanomedicine. 2012 Nov;8(8):1282-92. doi: 10.1016/j.nano.2012.02.012. Epub 2012 Mar 7. PubMed PMID: 22406188.
  • 117: Koch A, Zimmermann HW, Baeck C, Schneider C, Yagmur E, Trautwein C, Tacke F. Serum NT-proCNP concentrations are elevated in patients with chronic liver diseases and associated with complications and unfavorable prognosis of cirrhosis. Clin Biochem. 2012 Apr;45(6):429-35. doi: 10.1016/j.clinbiochem.2012.01.009. Epub 2012 Jan 18. PubMed PMID: 22285383.
  • 118: Schneider C, Teufel A, Yevsa T, Staib F, Hohmeyer A, Walenda G, Zimmermann HW, Vucur M, Huss S, Gassler N, Wasmuth HE, Lira SA, Zender L, Luedde T, Trautwein C, Tacke F. Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer. Gut. 2012 Dec;61(12):1733-43. doi: 10.1136/gutjnl-2011-301116. Epub 2012 Jan 20. PubMed PMID: 22267597; PubMed Central PMCID: PMC4533880.
  • 119: Zimmermann HW, Tacke F. Modification of chemokine pathways and immune cell infiltration as a novel therapeutic approach in liver inflammation and fibrosis. Inflamm Allergy Drug Targets. 2011 Dec;10(6):509-36. Review. PubMed PMID: 22150762.
  • 120: Tacke F, Weiskirchen R. Update on hepatic stellate cells: pathogenic role in liver fibrosis and novel isolation techniques. Expert Rev Gastroenterol Hepatol. 2012 Feb;6(1):67-80. doi: 10.1586/egh.11.92. Review. PubMed PMID: 22149583.
  • 121: Tacke F, Kurts C. Infiltrating monocytes versus resident Kupffer cells: do alternatively activated macrophages need to be targeted alternatively? Hepatology. 2011 Dec;54(6):2267-70. doi: 10.1002/hep.24714. PubMed PMID: 22139706.
  • 122: Zimmermann HW, Koch A, Seidler S, Trautwein C, Tacke F. Circulating soluble urokinase plasminogen activator is elevated in patients with chronic liver disease, discriminates stage and aetiology of cirrhosis and predicts prognosis. Liver Int. 2012 Mar;32(3):500-9. doi: 10.1111/j.1478-3231.2011.02665.x. Epub 2011 Oct 17. PubMed PMID: 22098627.
  • 123: Koch A, Horn A, Dückers H, Yagmur E, Sanson E, Bruensing J, Buendgens L, Voigt S, Trautwein C, Tacke F. Increased liver stiffness denotes hepatic dysfunction and mortality risk in critically ill non-cirrhotic patients at a medical ICU. Crit Care. 2011;15(6):R266. doi: 10.1186/cc10543. Epub 2011 Nov 14. PubMed PMID: 22082207; PubMed Central PMCID: PMC3388655.
  • 124: Heymann F, Hammerich L, Storch D, Bartneck M, Huss S, Rüsseler V, Gassler N, Lira SA, Luedde T, Trautwein C, Tacke F. Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice. Hepatology. 2012 Mar;55(3):898-909. doi: 10.1002/hep.24764. Epub 2012 Jan 13. PubMed PMID: 22031018; PubMed Central PMCID: PMC4533854.
  • 125: Liedtke C, Bangen JM, Freimuth J, Beraza N, Lambertz D, Cubero FJ, Hatting M, Karlmark KR, Streetz KL, Krombach GA, Tacke F, Gassler N, Riethmacher D, Trautwein C. Loss of caspase-8 protects mice against inflammation-related hepatocarcinogenesis but induces non-apoptotic liver injury. Gastroenterology. 2011 Dec;141(6):2176-87. doi: 10.1053/j.gastro.2011.08.037. Epub 2011 Aug 28. PubMed PMID: 21878202.
  • 126: Baeck C, Wehr A, Karlmark KR, Heymann F, Vucur M, Gassler N, Huss S, Klussmann S, Eulberg D, Luedde T, Trautwein C, Tacke F. Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. Gut. 2012 Mar;61(3):416-26. doi: 10.1136/gutjnl-2011-300304. Epub 2011 Aug 3. PubMed PMID: 21813474.
  • 127: Zimmermann HW, Seidler S, Gassler N, Nattermann J, Luedde T, Trautwein C, Tacke F. Interleukin-8 is activated in patients with chronic liver diseases and associated with hepatic macrophage accumulation in human liver fibrosis. PLoS One. 2011;6(6):e21381. doi: 10.1371/journal.pone.0021381. Epub 2011 Jun 22. PubMed PMID: 21731723; PubMed Central PMCID: PMC3120868.
  • 128: Tacke F, Zimmermann HW, Berres ML, Trautwein C, Wasmuth HE. Serum chemokine receptor CXCR3 ligands are associated with progression, organ dysfunction and complications of chronic liver diseases. Liver Int. 2011 Jul;31(6):840-9. doi: 10.1111/j.1478-3231.2011.02504.x. Epub 2011 Mar 10. PubMed PMID: 21645215.
  • 129: Tacke F, Kanig N, En-Nia A, Kaehne T, Eberhardt CS, Shpacovitch V, Trautwein C, Mertens PR. Y-box protein-1/p18 fragment identifies malignancies in patients with chronic liver disease. BMC Cancer. 2011 May 20;11:185. doi: 10.1186/1471-2407-11-185. PubMed PMID: 21595987; PubMed Central PMCID: PMC3120803.
  • 130: Henkel C, Schwamborn K, Zimmermann HW, Tacke F, Kühnen E, Odenthal M, Groseclose MR, Caprioli RM, Weiskirchen R. From proteomic multimarker profiling to interesting proteins: thymosin-β(4) and kininogen-1 as new potential biomarkers for inflammatory hepatic lesions. J Cell Mol Med. 2011 Oct;15(10):2176-88. doi: 10.1111/j.1582-4934.2010.01204.x. PubMed PMID: 21496200; PubMed Central PMCID: PMC4394227.
  • 131: Tacke F, Zimmermann HW, Trautwein C, Schnabl B. CXCL5 plasma levels decrease in patients with chronic liver disease. J Gastroenterol Hepatol. 2011 Mar;26(3):523-9. doi: 10.1111/j.1440-1746.2010.06436.x. PubMed PMID: 21332547; PubMed Central PMCID: PMC3058722.
  • 132: Koch A, Voigt S, Kruschinski C, Sanson E, Dückers H, Horn A, Yagmur E, Zimmermann H, Trautwein C, Tacke F. Circulating soluble urokinase plasminogen activator receptor is stably elevated during the first week of treatment in the intensive care unit and predicts mortality in critically ill patients. Crit Care. 2011;15(1):R63. doi: 10.1186/cc10037. Epub 2011 Feb 16. PubMed PMID: 21324198; PubMed Central PMCID: PMC3221996.
  • 133: Vucur M, Roderburg C, Bettermann K, Tacke F, Heikenwalder M, Trautwein C, Luedde T. Mouse models of hepatocarcinogenesis: what can we learn for the prevention of human hepatocellular carcinoma? Oncotarget. 2010 Sep;1(5):373-8. PubMed PMID: 21307402; PubMed Central PMCID: PMC3157729.
  • 134: Koch A, Voigt S, Sanson E, Dückers H, Horn A, Zimmermann HW, Trautwein C, Tacke F. Prognostic value of circulating amino-terminal pro-C-type natriuretic peptide in critically ill patients. Crit Care. 2011;15(1):R45. doi: 10.1186/cc10007. Epub 2011 Jan 31. PubMed PMID: 21281508; PubMed Central PMCID: PMC3221974.
  • 135: Berres ML, Trautwein C, Schmeding M, Eurich D, Tacke F, Bahra M, Neuhaus P, Neumann UP, Wasmuth HE. Serum chemokine CXC ligand 10 (CXCL10) predicts fibrosis progression after liver transplantation for hepatitis C infection. Hepatology. 2011 Feb;53(2):596-603. doi: 10.1002/hep.24098. Epub 2011 Jan 10. PubMed PMID: 21274880.
  • 136: Schirin-Sokhan R, Winograd R, Tischendorf S, Wasmuth HE, Streetz K, Tacke F, Trautwein C, Tischendorf JJ. Assessment of inflammatory and fibrotic stenoses in patients with Crohn's disease using contrast-enhanced ultrasound and computerized algorithm: a pilot study. Digestion. 2011;83(4):263-8. doi: 10.1159/000321389. Epub 2011 Jan 28. PubMed PMID: 21273775.
  • 137: Tacke F, Trautwein C. Controlling autophagy: a new concept for clearing liver disease. Hepatology. 2011 Jan;53(1):356-8. doi: 10.1002/hep.24090. PubMed PMID: 21254183.
  • 138: Hammerich L, Heymann F, Tacke F. Role of IL-17 and Th17 cells in liver diseases. Clin Dev Immunol. 2011;2011:345803. doi: 10.1155/2011/345803. Epub 2010 Dec 15. Review. PubMed PMID: 21197451; PubMed Central PMCID: PMC3010664.
  • 139: Karlmark KR, Zimmermann HW, Roderburg C, Gassler N, Wasmuth HE, Luedde T, Trautwein C, Tacke F. The fractalkine receptor CX₃CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes. Hepatology. 2010 Nov;52(5):1769-82. doi: 10.1002/hep.23894. PubMed PMID: 21038415.
  • 140: Koch A, Weiskirchen R, Sanson E, Zimmermann HW, Voigt S, Dückers H, Trautwein C, Tacke F. Circulating retinol binding protein 4 in critically ill patients before specific treatment: prognostic impact and correlation with organ function, metabolism and inflammation. Crit Care. 2010;14(5):R179. doi: 10.1186/cc9285. Epub 2010 Oct 8. PubMed PMID: 20932285; PubMed Central PMCID: PMC3219283.
  • 141: Roderburg C, Urban GW, Bettermann K, Vucur M, Zimmermann H, Schmidt S, Janssen J, Koppe C, Knolle P, Castoldi M, Tacke F, Trautwein C, Luedde T. Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis. Hepatology. 2011 Jan;53(1):209-18. doi: 10.1002/hep.23922. Epub 2010 Oct 1. PubMed PMID: 20890893.
  • 142: Amini-Bavil-Olyaee S, Herbers U, Luedde T, Trautwein C, Tacke F. Impact of hepatitis B e antigen-suppressing mutations on the replication efficiency of entecavir-resistant hepatitis B virus strains. J Viral Hepat. 2011 Nov;18(11):804-14. doi: 10.1111/j.1365-2893.2010.01378.x. Epub 2010 Sep 30. PubMed PMID: 20887378.
  • 143: Koch A, Weiskirchen R, Zimmermann HW, Sanson E, Trautwein C, Tacke F. Relevance of serum leptin and leptin-receptor concentrations in critically ill patients. Mediators Inflamm. 2010;2010. pii: 473540. doi: 10.1155/2010/473540. Epub 2010 Sep 7. PubMed PMID: 20871818; PubMed Central PMCID: PMC2943118.
  • 144: Koch A, Sanson E, Voigt S, Helm A, Trautwein C, Tacke F. Serum adiponectin upon admission to the intensive care unit may predict mortality in critically ill patients. J Crit Care. 2011 Apr;26(2):166-74. doi: 10.1016/j.jcrc.2010.07.015. PubMed PMID: 20869198.
  • 145: Wasmuth HE, Tacke F, Trautwein C. Chemokines in liver inflammation and fibrosis. Semin Liver Dis. 2010 Aug;30(3):215-25. doi: 10.1055/s-0030-1255351. Epub 2010 Jul 21. Review. PubMed PMID: 20665374.
  • 146: Zimmermann HW, Seidler S, Nattermann J, Gassler N, Hellerbrand C, Zernecke A, Tischendorf JJ, Luedde T, Weiskirchen R, Trautwein C, Tacke F. Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis. PLoS One. 2010 Jun 10;5(6):e11049. doi: 10.1371/journal.pone.0011049. PubMed PMID: 20548789; PubMed Central PMCID: PMC2883575.
  • 147: Sander LE, Sackett SD, Dierssen U, Beraza N, Linke RP, Müller M, Blander JM, Tacke F, Trautwein C. Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function. J Exp Med. 2010 Jul 5;207(7):1453-64. doi: 10.1084/jem.20091474. Epub 2010 Jun 7. PubMed PMID: 20530204; PubMed Central PMCID: PMC2901069.
  • 148: Koch A, Sanson E, Helm A, Voigt S, Trautwein C, Tacke F. Regulation and prognostic relevance of serum ghrelin concentrations in critical illness and sepsis. Crit Care. 2010;14(3):R94. doi: 10.1186/cc9029. Epub 2010 May 25. PubMed PMID: 20500817; PubMed Central PMCID: PMC2911731.
  • 149: Bettermann K, Vucur M, Haybaeck J, Koppe C, Janssen J, Heymann F, Weber A, Weiskirchen R, Liedtke C, Gassler N, Müller M, de Vos R, Wolf MJ, Boege Y, Seleznik GM, Zeller N, Erny D, Fuchs T, Zoller S, Cairo S, Buendia MA, Prinz M, Akira S, Tacke F, Heikenwalder M, Trautwein C, Luedde T. TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer. Cancer Cell. 2010 May 18;17(5):481-96. doi: 10.1016/j.ccr.2010.03.021. PubMed PMID: 20478530.
  • 150: Bomble M, Tacke F, Rink L, Kovalenko E, Weiskirchen R. Analysis of antigen-presenting functionality of cultured rat hepatic stellate cells and transdifferentiated myofibroblasts. Biochem Biophys Res Commun. 2010 May 28;396(2):342-7. doi: 10.1016/j.bbrc.2010.04.094. Epub 2010 Apr 18. PubMed PMID: 20403338.
  • 151: Amini-Bavil-Olyaee S, Pourkarim MR, Schaefer S, Mahboudi F, Van Ranst M, Adeli A, Trautwein C, Tacke F. Single-step real-time PCR to quantify hepatitis B virus and distinguish genotype D from non-D genotypes. J Viral Hepat. 2011 Apr;18(4):300-4. doi: 10.1111/j.1365-2893.2010.01308.x. PubMed PMID: 20367802.
  • 152: Tacke F, Weiskirchen R. [Liver fibrosis - pathogenesis and novel therapeutic approaches]. Internist (Berl). 2010 Jan;51(1):21-9. doi: 10.1007/s00108-009-2419-6. Review. German. PubMed PMID: 20012930.
  • 153: Tischendorf JJ, Schirin-Sokhan R, Streetz K, Gassler N, Hecker HE, Meyer M, Tacke F, Wasmuth HE, Trautwein C, Winograd R. Value of magnifying endoscopy in classifying colorectal polyps based on vascular pattern. Endoscopy. 2010 Jan;42(1):22-7. doi: 10.1055/s-0029-1215268. Epub 2009 Nov 6. PubMed PMID: 19899031.
  • 154: Amini-Bavil-Olyaee S, Vucur M, Luedde T, Trautwein C, Tacke F. Differential impact of immune escape mutations G145R and P120T on the replication of lamivudine-resistant hepatitis B virus e antigen-positive and -negative strains. J Virol. 2010 Jan;84(2):1026-33. doi: 10.1128/JVI.01796-09. Epub 2009 Nov 4. PubMed PMID: 19889778; PubMed Central PMCID: PMC2798356.
  • 155: Tacke F. [Monocyte subpopulations in inflammation processes: principles and perspectives]. Dtsch Med Wochenschr. 2009 Aug;134(33):1645-8. doi: 10.1055/s-0029-1233994. Epub 2009 Jul 31. Review. German. PubMed PMID: 19650028.
  • 156: Berres ML, Trautwein C, Zaldivar MM, Schmitz P, Pauels K, Lira SA, Tacke F, Wasmuth HE. The chemokine scavenging receptor D6 limits acute toxic liver injury in vivo. Biol Chem. 2009 Oct;390(10):1039-45. doi: 10.1515/BC.2009.119. PubMed PMID: 19642876.
  • 157: Amini-Bavil-Olyaee S, Herbers U, Mohebbi SR, Sabahi F, Zali MR, Luedde T, Trautwein C, Tacke F. Prevalence, viral replication efficiency and antiviral drug susceptibility of rtQ215 polymerase mutations within the hepatitis B virus genome. J Hepatol. 2009 Oct;51(4):647-54. doi: 10.1016/j.jhep.2009.04.022. Epub 2009 May 27. PubMed PMID: 19586679.
  • 158: Karlmark KR, Weiskirchen R, Zimmermann HW, Gassler N, Ginhoux F, Weber C, Merad M, Luedde T, Trautwein C, Tacke F. Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis. Hepatology. 2009 Jul;50(1):261-74. doi: 10.1002/hep.22950. PubMed PMID: 19554540.
  • 159: Koch A, Gressner OA, Sanson E, Tacke F, Trautwein C. Serum resistin levels in critically ill patients are associated with inflammation, organ dysfunction and metabolism and may predict survival of non-septic patients. Crit Care. 2009;13(3):R95. doi: 10.1186/cc7925. Epub 2009 Jun 19. PubMed PMID: 19545363; PubMed Central PMCID: PMC2717467.
  • 160: Heymann F, Trautwein C, Tacke F. Monocytes and macrophages as cellular targets in liver fibrosis. Inflamm Allergy Drug Targets. 2009 Sep;8(4):307-18. Review. PubMed PMID: 19534673.
  • 161: Wasmuth HE, Lammert F, Zaldivar MM, Weiskirchen R, Hellerbrand C, Scholten D, Berres ML, Zimmermann H, Streetz KL, Tacke F, Hillebrandt S, Schmitz P, Keppeler H, Berg T, Dahl E, Gassler N, Friedman SL, Trautwein C. Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans. Gastroenterology. 2009 Jul;137(1):309-19, 319.e1-3. doi: 10.1053/j.gastro.2009.03.053. Epub 2009 Apr 1. PubMed PMID: 19344719; PubMed Central PMCID: PMC2892869.
  • 162: Amini-Bavil-Olyaee S, Herbers U, Sheldon J, Luedde T, Trautwein C, Tacke F. The rtA194T polymerase mutation impacts viral replication and susceptibility to tenofovir in hepatitis B e antigen-positive and hepatitis B e antigen-negative hepatitis B virus strains. Hepatology. 2009 Apr;49(4):1158-65. doi: 10.1002/hep.22790. PubMed PMID: 19263474.
  • 163: Kovalenko E, Tacke F, Gressner OA, Zimmermann HW, Lahme B, Janetzko A, Wiederholt T, Berg T, Müller T, Trautwein C, Gressner AM, Weiskirchen R. Validation of connective tissue growth factor (CTGF/CCN2) and its gene polymorphisms as noninvasive biomarkers for the assessment of liver fibrosis. J Viral Hepat. 2009 Sep;16(9):612-20. doi: 10.1111/j.1365-2893.2009.01110.x. Epub 2009 Feb 20. PubMed PMID: 19243500.
  • 164: Amini-Bavil-Olyaee S, Sheldon J, Lutz T, Trautwein C, Tacke F. Molecular analysis of an HBsAg-negative hepatitis B virus mutant selected in a tenofovir-treated HIV-hepatitis B virus co-infected patient. AIDS. 2009 Jan 14;23(2):268-72. doi: 10.1097/QAD.0b013e3283224316. PubMed PMID: 19098499.
  • 165: Karlmark KR, Wasmuth HE, Trautwein C, Tacke F. Chemokine-directed immune cell infiltration in acute and chronic liver disease. Expert Rev Gastroenterol Hepatol. 2008 Apr;2(2):233-42. doi: 10.1586/17474124.2.2.233. Review. PubMed PMID: 19072358.
  • 166: Raffetseder U, Rauen T, Djudjaj S, Kretzler M, En-Nia A, Tacke F, Zimmermann HW, Nelson PJ, Frye BC, Floege J, Stefanidis I, Weber C, Mertens PR. Differential regulation of chemokine CCL5 expression in monocytes/macrophages and renal cells by Y-box protein-1. Kidney Int. 2009 Jan;75(2):185-96. doi: 10.1038/ki.2008.457. Epub 2008 Sep 17. PubMed PMID: 18800033.
  • 167: Sander LE, Obermeier F, Dierssen U, Kroy DC, Singh AK, Seidler U, Streetz KL, Lutz HH, Müller W, Tacke F, Trautwein C. Gp130 signaling promotes development of acute experimental colitis by facilitating early neutrophil/macrophage recruitment and activation. J Immunol. 2008 Sep 1;181(5):3586-94. PubMed PMID: 18714032.
  • 168: Tacke F, Luedde T, Trautwein C. Inflammatory pathways in liver homeostasis and liver injury. Clin Rev Allergy Immunol. 2009 Feb;36(1):4-12. doi: 10.1007/s12016-008-8091-0. Review. PubMed PMID: 18600481.
  • 169: Gressner OA, Koch A, Sanson E, Trautwein C, Tacke F. High C5a levels are associated with increased mortality in sepsis patients--no enhancing effect by actin-free Gc-globulin. Clin Biochem. 2008 Aug;41(12):974-80. doi: 10.1016/j.clinbiochem.2008.05.005. Epub 2008 May 27. PubMed PMID: 18538666.
  • 170: Tacke F, Trautwein C. Hepatitis B goes globe: Telbivudine as a new treatment option. Hepatology. 2008 May;47(5):1786-7. doi: 10.1002/hep.22299. PubMed PMID: 18438788.
  • 171: Malato Y, Sander LE, Liedtke C, Al-Masaoudi M, Tacke F, Trautwein C, Beraza N. Hepatocyte-specific inhibitor-of-kappaB-kinase deletion triggers the innate immune response and promotes earlier cell proliferation during liver regeneration. Hepatology. 2008 Jun;47(6):2036-50. doi: 10.1002/hep.22264. PubMed PMID: 18393321.
  • 172: Wasmuth HE, Zaldivar MM, Berres ML, Werth A, Scholten D, Hillebrandt S, Tacke F, Schmitz P, Dahl E, Wiederholt T, Hellerbrand C, Berg T, Weiskirchen R, Trautwein C, Lammert F. The fractalkine receptor CX3CR1 is involved in liver fibrosis due to chronic hepatitis C infection. J Hepatol. 2008 Feb;48(2):208-15. Epub 2007 Nov 20. PubMed PMID: 18078680.
  • 173: Zernecke A, Bot I, Djalali-Talab Y, Shagdarsuren E, Bidzhekov K, Meiler S, Krohn R, Schober A, Sperandio M, Soehnlein O, Bornemann J, Tacke F, Biessen EA, Weber C. Protective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils in atherosclerosis. Circ Res. 2008 Feb 1;102(2):209-17. Epub 2007 Nov 8. PubMed PMID: 17991882.
  • 174: Tacke F, Trautwein C. Efficient recombinant hepatitis E virus vaccine: mission accomplished? Hepatology. 2007 Sep;46(3):941-3. PubMed PMID: 17879359.
  • 175: Tacke F, Trautwein C, Yagmur E, Hellerbrand C, Wiest R, Brenner DA, Schnabl B. Up-regulated eotaxin plasma levels in chronic liver disease patients indicate hepatic inflammation, advanced fibrosis and adverse clinical course. J Gastroenterol Hepatol. 2007 Aug;22(8):1256-64. PubMed PMID: 17688666.
  • 176: Tacke F, Gäbele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C, Brenner DA, Schölmerich J, Schnabl B. Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells. Dig Dis Sci. 2007 Dec;52(12):3404-15. Epub 2007 Apr 6. PubMed PMID: 17415633.
  • 177: Tacke F, Trautwein C. Causes of death in hepatitis B and/or C virus infected-people - lessons for clinical practice. Hepatology. 2007 Apr;45(4):1076-7. PubMed PMID: 17393502.
  • 178: Tacke F, Fiedler K, Trautwein C. A simple clinical score predicts high risk for upper gastrointestinal hemorrhages from varices in patients with chronic liver disease. Scand J Gastroenterol. 2007 Mar;42(3):374-82. PubMed PMID: 17354118.
  • 179: Yagmur E, Weiskirchen R, Gressner AM, Trautwein C, Tacke F. Insulin resistance in liver cirrhosis is not associated with circulating retinol-binding protein 4. Diabetes Care. 2007 May;30(5):1168-72. Epub 2007 Mar 2. PubMed PMID: 17337499.
  • 180: Tacke F, Amini-Bavil-Olyaee S, Heim A, Luedde T, Manns MP, Trautwein C. Acute hepatitis B virus infection by genotype F despite successful vaccination in an immune-competent German patient. J Clin Virol. 2007 Apr;38(4):353-7. Epub 2007 Feb 26. PubMed PMID: 17324621.
  • 181: Tacke F, Trautwein C. Serum hepatitis B virus DNA level as a risk predictor for liver disease complications. Nat Clin Pract Gastroenterol Hepatol. 2006 Aug;3(8):426-7. PubMed PMID: 16883343.
  • 182: Yagmur E, Trautwein C, Gressner AM, Tacke F. Resistin serum levels are associated with insulin resistance, disease severity, clinical complications, and prognosis in patients with chronic liver diseases. Am J Gastroenterol. 2006 Jun;101(6):1244-52. PubMed PMID: 16771945.
  • 183: Yagmur E, Tacke F, Weiss C, Lahme B, Manns MP, Kiefer P, Trautwein C, Gressner AM. Elevation of Nepsilon-(carboxymethyl)lysine-modified advanced glycation end products in chronic liver disease is an indicator of liver cirrhosis. Clin Biochem. 2006 Jan;39(1):39-45. PubMed PMID: 16321365.